Human Interferon Beta 1a, mammalian 11410-2 from PBL Assay Science

Product Specs
ItemHuman Interferon Beta 1a, mammalian
CompanyPBL Assay Science
Price Pricing Info Supplier Page View Company Product Page
Catalog Number11410-2
Purity>95%
SpeciesHuman
Molecule NameIFN-Beta
ActivityActivity: 4.0 x 10⁸ u/mg
Format10 mM Acetic Acid
Source/Expression SystemCHO
Quantity1 x 106 Units
Gene Nameinterferon, beta 1, fibroblast
Brand/TrademarkPBL Assay Science
TypeProtein
Molecular Weight~23 kDa
NCBI Full Gene Nameinterferon beta 1
NCBI Gene AliasesIFB, IFF, IFN-beta, IFNB

Specifications/Features

Protein Specific Information:
, carrier-free

Additional Product Information

Protein/Peptide:
IFN Beta 1a

Protein/Peptide Species:
Human

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PBL Assay Science

131 Ethel Road West. Suite 6

Piscataway, New Jersey

United States

Phone: 1-877-725-8881
1-732-777-9123
1-732-777-9141

Company Profile

Website: www.pblassaysci.com

(1) Subsets of IFN Signaling Predict Response to Immune Checkpoint Blockade in Patients with MelanomaClinical cancer research : an official journal of the American Association for Cancer ResearchAugust 1, 2023Horowitch B, Lee DY, Ding M, Martinez-Morilla S, Aung TN, Ouerghi F, Wang X, Wei W, Damsky W, Sznol M, et al.carcinoma (RRID:CVCL_0023) cell lines were untreated or stimulated with 1000 U/mL IFNβ (PBL Assay Science 11410–2) or 100 ng/mL IFNγ (PBL Assay Science 11500–2) for 48h. Cells were pelleted, resuspended in 10% neutral

(2) Mapping interindividual dynamics of innate immune response at single-cell resolutionNature GeneticsJune 12, 2023Natsuhiko Kumasaka, Raghd Rostom, Ni Huang, Krzysztof Polanski, Kerstin B. Meyer, Sharad Patel, Rachel Boyd, Celine Gomez, Sam N. Barnett, Nikolaos I. Panousis, et al.lipofectamine 2000 (Thermo Fisher, 11668027), for 2 or 6 h) or 1,000 U ml−1 human recombinant IFN-β (11410-2, PBL), for 2 or 6 h, or left untreated. In this manner, for each individual, we obtained five separate

(3) Attenuation of SARS-CoV-2 replication and associated inflammation by concomitant targeting of viral and host cap 2'-O-ribose methyltransferasesThe EMBO journalSeptember 1, 2022Bergant V, Yamada S, Grass V, Tsukamoto Y, Lavacca T, Krey K, Mühlhofer MT, Wittmann S, Ensser A, Herrmann A, et al.(Bélanger et al, 2010). Briefly, A549 cells with or without overnight IFN‐β 1a (PBL Assay Science, 11410‐2) treatment (1,000 U/ml) were detached from cell culture dish and resuspended in 600 μl of cold lysis

(4) Direct type I interferon signaling in hepatocytes controls malariaCell ReportsJuly 19, 2022Camila Marques-da-Silva, Kristen Peissig, Michael P. Walker, Justine Shiau, Carson Bowers, Dennis E. Kyle, Rahul Vijay, Scott E. Lindner, Samarchith P. Kurup12410-1 Recombinant human IFNα,PBL assay science,Cat#11101-1 Recombinant human IFNβ,PBL assay science,Cat# 11410-2 Penicillin-Streptomycin-Neomycin (PSN) Antibiotic,Gibco,Cat# 15640055 Gentamicin,Gibco,Cat# 15710072 Trypsin-EDTA,Corning,Cat#

(5) The RNA helicase DHX16 recognizes specific viral RNA to trigger RIG-I-dependent innate antiviral immunityCell reportsMarch 8, 2022Hage A, Bharaj P, van Tol S, Giraldo MI, Gonzalez-Orozco M, Valerdi KM, Warren AN, Aguilera-Aguirre L, Xie X, Widen SG, et al.#tlrl-hprna Biotin-labeled Poly(I:C) HMW,InvivoGen,Cat #tlrl-picb IFN-β 1a,PBL Assay Science,Cat #11410-2 N-ethylmaleimide,Sigma-Aldrich,Cat #E3876-25G Iodoacetamide,Sigma-Aldrich,Cat #I1149-25G FLAG peptide,Sigma-Aldrich,Cat

(6) Mechanistic insights into COVID-19 by global analysis of the SARS-CoV-2 3CL^pro substrate degradomeCell reportsOctober 26, 2021Pablos I, Machado Y, de Jesus HCR, Mohamud Y, Kappelhoff R, Lindskog C, Vlok M, Bell PA, Butler GS, Grin PM, et al.Flintbox,www.bit.ly/3iHPs8P IFN-α2a (carrier free),PBL Assay Science,Cat#11101-2 IFN-β1a (carrier free),PBL Assay Science,Cat#11410-2 Imperial protein stain,Thermo Fisher Scientific,Cat#24617 "importin subunit alpha-4 (IMA4), partial

(7) Ubiquitin-Specific Protease 6 Functions as a Tumor Suppressor in Ewing Sarcoma through Immune ActivationCancer ResearchApril 15, 2021Ian C. Henrich, Kanika Jain, Robert Young, Laura Quick, Jarrett M. Lindsay, Daniel H. Park, Andre M. Oliveira, Gerd A. Blobel, Margaret M. Chou(#8634-1); Jak Inhibitor I (#420099) and PS-1145 (P6624), Sigma. IFN α and β were from PBL Assay Science (#11410-2 and #11200-1), and IFNγ from PeproTech (#300-02). Lipofectamine 2000 was from Life Technologies. Flow

(8) Tissue alarmins and adaptive cytokine induce dynamic and distinct transcriptional responses in tissue-resident intraepithelial cytotoxic T lymphocytesJournal of autoimmunityMarch 1, 2020Zorro MM, Aguirre-Gamboa R, Mayassi T, Ciszewski C, Barisani D, Hu S, Weersma RK, Withoff S, Li Y, Wijmenga C, et al.Biolegend, cat 570304), IL-21 (3 ng/ml, Biolegend, cat 571204) or IFNβ (300 ng/ml, Pbl Assay science, cat 11410-2). Unstimulated IE-CTLs were included as control. Prior to the assay, the induction of granzyme B (GZMB),

(9) TRIM5α Restricts Flavivirus Replication by Targeting the Viral Protease for Proteasomal DegradationCell reportsJune 11, 2019Chiramel AI, Meyerson NR, McNally KL, Broeckel RM, Montoya VR, Méndez-Solís O, Robertson SJ, Sturdevant GL, Lubick KJ, Nair V, et al.Dead Cell Stain Kit,ThermoFisher Scientific,Cat #L34957 Interferon β (IFNβ),PBL Assay Science,Cat #11410-2 ECL Plus detection reagent,GE Healthcare,Cat #RPN2132 Lipofectamine RNAiMAX Transfection Reagent,Thermo Fisher Scientific

(10) USP6 Confers Sensitivity to IFN-Mediated Apoptosis through Modulation of TRAIL Signaling in Ewing SarcomaMolecular cancer research : MCRDecember 1, 2018Henrich IC, Young R, Quick L, Oliveira AM, Chou MM.Lipofectamine 2000 was from Life Technologies. Interferon α, β, and γ were obtained PBL Assay Science (#11410–2 and #11200–1) and PeproTech (#300–02) respectively. ZVAD (FMK001) and IETD (FMK007) were from R&D Systems.

(11) Gene expression variability across cells and species shapes innate immunityNatureNovember 1, 2018Tzachi Hagai et al.transfected with Lipofectamin 2,000; (3) stimulated with 1,000 IU of IFNB for 8 hours (human IFNB - 11410-2 (for human and macaque cells); rat IFNB - 13400-1; mouse IFNB – 12401-1; all IFNs were obtained from

(12) Histone chaperone HIRA deposits histone H3.3 onto foreign viral DNA and contributes to anti-viral intrinsic immunityNucleic Acids ResearchNovember 16, 2017Taranjit Singh Rai, Mandy Glass, John J. Cole, Mohammad I. Rather, Morgan Marsden, Matthew Neilson, Claire Brock, Ian R. Humphreys, Roger D. Everett, Peter D. Adamscontinuous antibiotic selection, as appropriate. Recombinant IFNs were bought from PBL (Human IFN-β -11410–2) and Sigma (IFN-α-SRP4596 and IFN-γ-I3265). ELISA (PBL Assay Science 41410) was performed according

(13) Single-cell analysis of early antiviral gene expression reveals a determinant of stochasticIFNB1expressionIntegrative BiologyNovember 13, 2017Sultan Doğanay, Maurice Youzong Lee, Alina Baum, Jessie Peh, Sun-Young Hwang, Joo-Yeon Yoo, Paul J. Hergenrother, Adolfo García-Sastre, Sua Myong, Taekjip Ha5. IFN-β treatments were carried out by adding 1000 units/ml of human IFN-β (PBL InterferonSource, 11410-2). Type I IFN activity was blocked by addition of 10 μg/ml of anti-IFN-α (Abcam, ab20200), 10 μg/ml anti-IFN-β

(14) Original Chemical Series of Pyrimidine Biosynthesis Inhibitors That Boost the Antiviral Interferon ResponseAntimicrobial Agents and ChemotherapyOctober 1, 2017Marianne Lucas-Hourani, Daniel Dauzonne, Hélène Munier-Lehmann, Samira Khiar, Sébastien Nisole, Julien Dairou, Olivier Helynck, Philippe V. Afonso, Frédéric Tangy, Pierre-Olivier Vidalainsynthesis. Uridine, orotate, dihydroorotate, brequinar sodium salt, and dicoumarol were from Sigma-Aldrich. IFN-β (11410-2) was from PBL Biomedical Laboratories. Short synthetic 5′-triphosphate RNA molecules (ssRNA) were synthesized

(15) Mass cytometry identifies a distinct monocyte cytokine signature shared by clinically heterogeneous pediatric SLE patientsJournal of AutoimmunityJuly 1, 2017William E. O'Gorman, Daniel S. Kong, Imelda M. Balboni, Pratryaydipta Rudra, Christopher R. Bolen, Debashish Ghosh, Mark M. Davis, Garry P. Nolan, Elena Wen-Yuan Hsiehof the following: recombinant human IFNα (25,000 units/ml; PBL 11100–1), IFNβ (25,000 units/ml; PBL 11410–2), IFNω (100 ng/ml, 1 μg/ml, and 10 μg/ml; Sigma SRP3061-100 UG), IFNγ (1 μg/ml), and IFNλ (50 ng/ml,

(16) Identification of a small molecule that primes the type I interferon response to cytosolic DNAScientific reportsMay 31, 2017Khiar S, Lucas-Hourani M, Nisole S, Smith N, Helynck O, Bourgine M, Ruffié C, Herbeuval JP, Munier-Lehmann H, Tangy F, et al.Stratagene (Ref 219089 and 219078, respectively). Recombinant IFN-β was from PBL Assay Science (Ref 11410-2). Recombinant TNF-α was from R&D Systems (Ref 210-TA). Short synthetic 5′-triphosphate RNA molecules

(17) La Piedad Michoacán Mexico Virus V protein antagonizes type I interferon response by binding STAT2 protein and preventing STATs nuclear translocationVirus ResearchFebruary 2, 2016Giuseppe Pisanelli, Maudry Laurent-Rolle, Balaji Manicassamy, Alan Belicha-Villanueva, Juliet Morrison, Bernardo Lozano-Dubernard, Felipa Castro-Peralta, Giuseppe Iovane, Adolfo García-Sastre.plasmids. Twentyfour hours post-transfection, cells were washed and treated with 1000 U/ml IFN beta 1a (PBL 11410-2). Sixteen hours post-IFN treatment, cells were harvested using reporter lysis buffer (Promega, cat no

(18) Herpes Simplex Virus 1 ICP22 but Not U _S 1.5 Is Required for Efficient Acute Replication in Mice and VICE Domain FormationJournal of VirologyDecember 15, 2013Heba H. Mostafa, David J. Davidoabove, with the exception that HEL-299 cells and MEFs were pretreated with human IFN-␤ (catalog number 11410-2; PBL InterferonSource) or mouse IFN-␤ (catalog number 12400-1; PBL InterferonSource), respectively,

(19) Interferon-kappa, a novel type I interferon expressed in human keratinocytesThe Journal of biological chemistryOctober 26, 2001D W LaFleur, B Nardelli, T Tsareva, D Mather, P Feng, M Semenuk, K Taylor, M Buergin, D Chinchilla, V Roshke, G Chen, S M Ruben, P M Pitha, T A Coleman, P A Moore

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Human Interferon Beta 1a, mammalian from PBL Assay Science

Description

Specifications/Features

Additional Product Information

PBL Assay Science

Citations (19)

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Human Interferon Beta 1a, mammalian from PBL Assay Science

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